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The chat2 (Connecting Health and Technology 2) study is a 1-year randomized controlled trial (RCT). Consenting participants will be randomly assigned (1:1) to an intervention or minimal intervention control group. Figure 1 shows the CONSORT (Consolidated Standards of Reporting Trials) study design. Assessments will occur at 0, 6, and 12 months with the primary outcome assessed at 12 months.
Study design with randomization to two groups: intervention and control groups.
JMIR Res Protoc 2025;14:e64735
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In March 2019 (after several months of prestudy collaboration), we began the Transitioning Youth Out of Homelessness (TYOH) study, a 2.5-year pilot community-based mixed method randomized controlled trial (RCT) with youth (mean age 22 years) from 3 cities in the province of Ontario [9]. All participants (n=24) received portable rent subsidies (ie, subsidies not tied to a specific location) for 2 years; 13 were randomly assigned an adult mentor.
JMIR Res Protoc 2025;14:e66210
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However, this research still followed the traditional CBT-I structure (ie, 6 weekly sessions lasting 90-120 minutes) and was not tested in a randomized controlled trial (RCT) [31]. While mindfulness is often incorporated as part of the cognitive component of CBT-I [32], the Headspace Sleep Program positions mindfulness as a foundational approach, introducing it first as a tool for building awareness of sleep habits and patterns.
JMIR Mhealth Uhealth 2025;13:e68665
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We conducted a single-center, 3-arm parallel pilot randomized controlled trial (RCT) to explore the effect of a smartphone app self-management program on clinical health outcomes in adults with COPD on a longitudinal basis of 12 months. The main components of this self-management program were monthly education, symptom tracking, communication with a health care professional, goal setting, and weekly motivational messages from the app.
JMIR Mhealth Uhealth 2025;13:e56318
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In the published results of this randomized controlled trial (RCT), it was found that primiparous women who received the Essential Coaching for Every Mother program had higher parenting self-efficacy at 6 weeks postbirth than those who did not receive the intervention [11]. Additionally, all mothers (regardless of parity) who received the intervention had lower postpartum anxiety symptoms than mothers who did not receive the intervention [11].
JMIR Pediatr Parent 2025;8:e62841
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In support of this, a standardized patient education and follow-up intervention for oral chemotherapy by Tokdemir and Kav [33] successfully increased medication adherence SE after the intervention (66.39 vs 71.04; P
The aim of this pilot randomized controlled trial (RCT) was to document the feasibility and acceptability of the experimental intervention. Pilot studies are critically important as a first step to address practical, logistical, and methodological issues that may arise.
JMIR Res Protoc 2025;14:e55475
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One RCT included a sample of patients with breast cancer treated with NACT (B-RCT), and the other included a sample of patients with prostate cancer treated with RT (P-RCT). In both RCTs, patients were randomly allocated to the intervention or control group. In the B-RCT, there were 74 patients in the intervention group and 75 patients in the control group.
JMIR Cancer 2025;11:e53539
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