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Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder in which there is a gradual degeneration of motor neurons due to a loss-of-function mutation in the survival of motor neuron 1 (SMN1) gene, which enables proper functioning of motor neurons and therefore muscle function [1-3]. There are 3 pediatric subtypes (types I, II, and III) of SMA based on the age of onset of muscle weakness and motor milestones achieved [3]. All SMA subtypes demonstrate a decline in function over time.
JMIR Res Protoc 2023;12:e46363
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However, preneoplastic conditions, such as atrophy and IM, require regular monitoring to detect developing neoplastic lesions [5,6]. Evidence for the recommended screening endoscopy time interval is lacking; however, a shorter interval is generally recommended for patients with atrophy or IM compared to those without [5-7].
J Med Internet Res 2023;25:e50448
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