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Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Death during the early phase of trauma is primarily attributable to uncontrolled bleeding, which is exacerbated by trauma-induced coagulopathy (TIC) [2-4]. Pathophysiology and clinical aspects of TIC comprise blood loss, consumption of coagulation factors, dilution, and fibrinolytic activation [2-5]. TIC correlates with an increased demand for massive transfusion as well as higher mortality. Thus, effective treatment of TIC is crucial for decreasing deaths following trauma [3-5].
JMIR Res Protoc 2023;12:e49582
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