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Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

The personalized trials framework is a unique pathway to achieve this. Personalized trials are trials that focus on or are tailored to a single person [24]. A special case is the personalized N-of-1 trial, which is a randomized clinical trial conducted at the level of the individual [25]. Personalized trials have several advantages.

Lindsay Arader, Danielle Miller, Alexandra Perrin, Frank Vicari, Ciaran P Friel, Elizabeth A Vrany, Ashley M Goodwin, Mark Butler

J Med Internet Res 2025;27:e54629

Digital Health Innovations to Catalyze the Transition to Value-Based Health Care

Digital Health Innovations to Catalyze the Transition to Value-Based Health Care

According to the Food and Drug Administration, digital health encompasses a range of technologies, including mobile health (m Health), health information technology, wearable devices, telehealth, telemedicine, and personalized medicine [1]. The adoption of health technologies is increasingly common in the health care industry, offering prospects for improved diagnostic accuracy, treatment options, and overall health outcomes [2].

Lan Zhang, Christopher Bullen, Jinsong Chen

JMIR Med Inform 2025;13:e57385

A Roadmap for Using Causal Inference and Machine Learning to Personalize Asthma Medication Selection

A Roadmap for Using Causal Inference and Machine Learning to Personalize Asthma Medication Selection

To shift asthma care from one-size-fits-all to personalized care, improve outcomes, and save health care resources, we make three contributions in this paper, supplying a roadmap for future research: (1) we point out the above-mentioned need for creating a decision support tool to guide ICS selection; (2) we point out the above-mentioned gap in fulfilling this need; and (3) to close this gap, we outline an approach to create a machine learning model and apply causal inference to predict a patient’s ICS response

Flory L Nkoy, Bryan L Stone, Yue Zhang, Gang Luo

JMIR Med Inform 2024;12:e56572

Cocreation to Facilitate Communication and Collaboration Between Multidisciplinary Stakeholders in eHealth Research and Development: Case Study of the CARRIER (Coronary Artery Disease: Risk Estimations and Interventions for Prevention and Early Detection) Consortium

Cocreation to Facilitate Communication and Collaboration Between Multidisciplinary Stakeholders in eHealth Research and Development: Case Study of the CARRIER (Coronary Artery Disease: Risk Estimations and Interventions for Prevention and Early Detection) Consortium

The CARRIER consortium is a Dutch initiative in the South Limburg region that aims to reduce the burden of atherosclerotic cardiovascular disease (ASCVD) with the help of a personalized e Health intervention. The consortium consists of experts in health and medicine, big data science, software development, and, lastly, ethical and legal experts in the medical domain.

Elizabeth Latuapon, Laura Hochstenbach, Dominik Mahr, Bart Scheenstra, Bas Kietselaer, Marieke Spreeuwenberg

JMIR Hum Factors 2023;10:e45006

An Evidence-Based Framework for Creating Inclusive and Personalized mHealth Solutions—Designing a Solution for Medicaid-Eligible Pregnant Individuals With Uncontrolled Type 2 Diabetes

An Evidence-Based Framework for Creating Inclusive and Personalized mHealth Solutions—Designing a Solution for Medicaid-Eligible Pregnant Individuals With Uncontrolled Type 2 Diabetes

We use our ACHIEVE (successfully achieving and maintaining euglycemia during pregnancy for type 2 diabetes through technology and coaching) solution as the basis to address these knowledge gaps by proposing an evidence-based framework for designing m Health apps that is both inclusive and personalized. This framework demonstrates how the design, implementation, and evaluation of such tools, driven by the principles of UCD, can be collectively undertaken for any digital health tool.

Naleef Fareed, Christine Swoboda, Yiting Wang, Robert Strouse, Jenelle Hoseus, Carrie Baker, Joshua J Joseph, Kartik Venkatesh

JMIR Diabetes 2023;8:e46654

Patients’ Experiences Using a Mobile Health App for Self-Care of Heart Failure in a Real-World Setting: Qualitative Analysis

Patients’ Experiences Using a Mobile Health App for Self-Care of Heart Failure in a Real-World Setting: Qualitative Analysis

The mobile app has the following six main components: (1) a home screen that is personalized to display the 42 self-care features such as daily medications, exercise, sodium intake, general health status, and telemonitored physiological variables that were assigned to patients based on their tailored needs; (2) invasive remote monitoring interfaces for Cardio MEMS hemodynamic sensor and left ventricular-assisted devices; (3) a medication tab that shows an active medication list and direction for taking each medication

Ifeanyi Madujibeya, Terry A Lennie, Jamie Pelzel, Debra K Moser

JMIR Form Res 2023;7:e39525

A Series of Remote Melatonin Supplement Interventions for Poor Sleep: Protocol for a Feasibility Pilot Study for a Series of Personalized (N-of-1) Trials

A Series of Remote Melatonin Supplement Interventions for Poor Sleep: Protocol for a Feasibility Pilot Study for a Series of Personalized (N-of-1) Trials

Because of this variability in treatment provision and response, participants taking melatonin may benefit from a personalized (N-of-1) trial approach [29,30]. Personalized trials are a research approach that helps participants to select which treatments work best for them individually. Participants in a personalized N-of-1 trial receive a multiple crossover trial with continuous collection of objective outcome data throughout the trial.

Mark Butler, Stefani D’Angelo, Alexandra Perrin, Jordyn Rodillas, Danielle Miller, Lindsay Arader, Thevaa Chandereng, Ying Kuen Cheung, Ari Shechter, Karina W Davidson

JMIR Res Protoc 2023;12:e45313

Factors Predicting Older People’s Acceptance of a Personalized Health Care Service App and the Effect of Chronic Disease: Cross-Sectional Questionnaire Study

Factors Predicting Older People’s Acceptance of a Personalized Health Care Service App and the Effect of Chronic Disease: Cross-Sectional Questionnaire Study

In this study, we examine the acceptability of a personalized health care service app that we are currently developing. Research on technology acceptance commonly uses the technology acceptance model (TAM) and the unified theory of acceptance and use of technology (UTAUT).

Jun Hyuk Koo, You Hyun Park, Dae Ryong Kang

JMIR Aging 2023;6:e41429

A Personalized Mobile Cessation Intervention to Promote Smokers From the Preparation Stage to the Action Stage: Double-blind Randomized Controlled Trial

A Personalized Mobile Cessation Intervention to Promote Smokers From the Preparation Stage to the Action Stage: Double-blind Randomized Controlled Trial

The purpose of this study was to evaluate the changes in protection motivation theory (PMT) subconstructs and the transtheoretical model (TTM) stages of change to provide insight into why a personalized mobile cessation intervention was more likely to promote smokers from the preparation stage to the action stage.

Haoxiang Lin, Ying Wang, Yanling Xing, Yinglian Han, Chengqian Zhang, Ting Luo, Chun Chang

J Med Internet Res 2023;25:e41911

Examining the Individual Response to a Low-Sodium Diet in Patients with Hypertension: Protocol for a Pilot Randomized Controlled Trial

Examining the Individual Response to a Low-Sodium Diet in Patients with Hypertension: Protocol for a Pilot Randomized Controlled Trial

Precision or personalized nutrition focuses on ways to deliver tailored dietary recommendations to promote and maintain health and prevent disease [17]. However, this field is in its infancy and currently has limited clinical applicability to CVD. Metabolomics can measure the full profile of small-molecule metabolites in biofluids and provide a comprehensive picture of a person’s overall dietary intake [18].

Jisook Ko, Jing Wang, Misook L Chung, Kumar Sharma

JMIR Res Protoc 2023;12:e39058