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Considering a moderate-to-severe COVID-19 rate as the dependent variable, a rate which the current literature estimates to be 20% [4,6,10-18,40-42] as well as the proportion of 1 case for every 2 controls, the sample calculation was approximately 3000 antimalarial users and 6000 nonusers, with an error α=5% and β=20%.
JMIR Res Protoc 2020;9(10):e23532
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