Foundation Models and Their Applications in AI

Performance of Large Language Models in Numerical Versus Semantic Medical Knowledge: Cross-Sectional Benchmarking Study on Evidence-Based Questions and Answers

Eden Avnat, Michal Levy, Daniel Herstain, Elia Yanko, Daniel Ben Joya, Michal Tzuchman Katz, Dafna Eshel, Sahar Laros, Yael Dagan, Shahar Barami, Joseph Mermelstein, Shahar Ovadia, Noam Shomron, Varda Shalev, Raja-Elie E Abdulnour

J Med Internet Res 2025 (Jul 14); 27:e64452

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Language Models for Multilabel Document Classification of Surgical Concepts in Exploratory Laparotomy Operative Notes: Algorithm Development Study

Jeremy A Balch, Sasank S Desaraju, Victoria J Nolan, Divya Vellanki, Timothy R Buchanan, Lindsey M Brinkley, Yordan Penev, Ahmet Bilgili, Aashay Patel, Corinne E Chatham, David M Vanderbilt, Rayon Uddin, Azra Bihorac, Philip Efron, Tyler J Loftus, Protiva Rahman, Benjamin Shickel

JMIR Med Inform 2025 (Jul 09); 13:e71176

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AI in Qualitative Health Research Appraisal: Comparative Study

August Landerholm

JMIR Form Res 2025 (Jul 08); 9:e72815

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Leveraging Large Language Models for Accurate Retrieval of Patient Information From Medical Reports: Systematic Evaluation Study

Angel Manuel Garcia-Carmona, Maria-Lorena Prieto, Enrique Puertas, Juan-Jose Beunza

JMIR AI 2025 (Jul 03); 4:e68776

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ChatGPT-Assisted Deep Learning Models for Influenza-Like Illness Prediction in Mainland China: Time Series Analysis

Weihong Huang, Wudi Wei, Xiaotao He, Baili Zhan, Xiaoting Xie, Meng Zhang, Shiyi Lai, Zongxiang Yuan, Jingzhen Lai, Rongfeng Chen, Junjun Jiang, Li Ye, Hao Liang

J Med Internet Res 2025 (Jun 27); 27:e74423

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Digital Phenotyping for Detecting Depression Severity in a Large Payor-Provider System: Retrospective Study of Speech and Language Model Performance

Bradley Karlin, Doug Henry, Ryan Anderson, Salvatore Cieri, Michael Aratow, Elizabeth Shriberg, Michelle Hoy

JMIR AI 2025 (Jun 19); 4:e69149

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Supervised Natural Language Processing Classification of Violent Death Narratives: Development and Assessment of a Compact Large Language Model

Susan T Parker

JMIR AI 2025 (Jun 19); 4:e68212

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Large Language Model Architectures in Health Care: Scoping Review of Research Perspectives

Florian Leiser, Richard Guse, Ali Sunyaev

J Med Internet Res 2025 (Jun 19); 27:e70315

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Analysis of the Political Viewpoint of Policy Statements From Professional Medical Organizations Using ChatGPT With GPT-4: Cross-Sectional Study

Ben Knudsen, Amr Madkour, Preetam Cholli, Alyson Haslam, Vinay Prasad

JMIR Form Res 2025 (Jun 13); 9:e66204

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Enhancing Pulmonary Disease Prediction Using Large Language Models With Feature Summarization and Hybrid Retrieval-Augmented Generation: Multicenter Methodological Study Based on Radiology Report

Ronghao Li, Shuai Mao, Congmin Zhu, Yingliang Yang, Chunting Tan, Li Li, Xiangdong Mu, Honglei Liu, Yuqing Yang

J Med Internet Res 2025 (Jun 11); 27:e72638

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A Knowledge-Enhanced Platform (MetaSepsisKnowHub) for Retrieval Augmented Generation–Based Sepsis Heterogeneity and Personalized Management: Development Study

Chi Zhang, Hao Yang, Xingyun Liu, Rongrong Wu, Hui Zong, Erman Wu, Yi Zhou, Jiakun Li, Bairong Shen

J Med Internet Res 2025 (Jun 06); 27:e67201

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Enhancing the Readability of Online Patient Education Materials Using Large Language Models: Cross-Sectional Study

John Will, Mahin Gupta, Jonah Zaretsky, Aliesha Dowlath, Paul Testa, Jonah Feldman

J Med Internet Res 2025 (Jun 04); 27:e69955

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Trajectory-Ordered Objectives for Self-Supervised Representation Learning of Temporal Healthcare Data Using Transformers: Model Development and Evaluation Study

Ali Amirahmadi, Farzaneh Etminani, Jonas Björk, Olle Melander, Mattias Ohlsson

JMIR Med Inform 2025 (Jun 04); 13:e68138

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High-Throughput Phenotyping of the Symptoms of Alzheimer Disease and Related Dementias Using Large Language Models: Cross-Sectional Study

You Cheng, Mrunal Malekar, Yingnan He, Apoorva Bommareddy, Colin Magdamo, Arjun Singh, Brandon Westover, Shibani S Mukerji, John Dickson, Sudeshna Das

JMIR AI 2025 (Jun 03); 4:e66926

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Algorithmic Classification of Psychiatric Disorder–Related Spontaneous Communication Using Large Language Model Embeddings: Algorithm Development and Validation

Ryan Allen Shewcraft, John Schwarz, Mariann Micsinai Balan

JMIR AI 2025 (May 30); 4:e67369

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Is This Chatbot Safe and Evidence-Based? A Call for the Critical Evaluation of Generative AI Mental Health Chatbots

Acacia Parks, Eoin Travers, Ramesh Perera-Delcourt, Max Major, Marcos Economides, Phil Mullan

J Particip Med 2025 (May 29); 17:e69534

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Use of ChatGPT for Urinary Symptom Management Among People With Spinal Cord Injury or Disease: Qualitative Study

Bat-Zion Hose, Amanda K Rounds, Ishaan Nandwani, Deanna-Nicole Busog, Traber Davis Giardina, Helen Haskell, Kelly M Smith, Kristen E Miller

JMIR Rehabil Assist Technol 2025 (May 29); 12:e70339

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Large Language Models as a Consulting Hotline for Patients With Breast Cancer and Specialists in China: Cross-Sectional Questionnaire Study

Hui Liu, Jialun Peng, Lu Li, Ao Deng, XiangXin Huang, Guobing Yin, Haojun Luo

JMIR Med Inform 2025 (May 27); 13:e66429

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Benchmarking the Confidence of Large Language Models in Answering Clinical Questions: Cross-Sectional Evaluation Study

Mahmud Omar, Reem Agbareia, Benjamin S Glicksberg, Girish N Nadkarni, Eyal Klang

JMIR Med Inform 2025 (May 16); 13:e66917

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Patient Triage and Guidance in Emergency Departments Using Large Language Models: Multimetric Study

Chenxu Wang, Fei Wang, Shuhan Li, Qing-wen Ren, Xiaomei Tan, Yaoyu Fu, Di Liu, Guangwu Qian, Yu Cao, Rong Yin, Kang Li

J Med Internet Res 2025 (May 15); 27:e71613

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